High density lipoproteins (HDLs) have a number of properties that have the potential to inhibit the development of atherosclerosis and thus reduce the risk of having a cardiovascular event. These protective effects of HDLs may be reduced in patients with type 2 diabetes, a condition in which the concentration of HDL cholesterol is frequently low. In addition to their potential cardioprotective properties, HDLs also increase the uptake of glucose by skeletal muscle and stimulate the synthesis and secretion of insulin from pancreatic β cells and may thus have a beneficial effect on glycemic control. This raises the possibility that a low HDL concentration in type 2 diabetes may contribute to a worsening of diabetic control. Thus, there is a double case for targeting HDLs in patients with type 2 diabetes: to reduce cardiovascular risk and also to improve glycemic control. Approaches to raising HDL levels include lifestyle factors such as weight reduction, increased physical activity and stopping smoking. There is an ongoing search for HDL-raising drugs as agents to use in patients with type 2 diabetes in whom the HDL level remains low despite lifestyle interventions.

Citations

Citations to this article as recorded by  

• Association between high-density lipoprotein cholesterol and type 2 diabetes mellitus: dual evidence from NHANES database and Mendelian randomization analysis
  Zhaoqi Yan, Yifeng Xu, Keke Li, Liangji Liu
  Frontiers in Endocrinology.2024;[Epub]     CrossRef
• Correlation of serum HDL level with HRV indices using multiple linear regression analysis in patients with type 2 diabetes mellitus
  Fareedabanu A. Balikai, Shivalingappa B. Javali, Varsha M. Shindhe, Neeta Deshpande, Jyoti M. Benni, Darshit P. Shetty, Nitin Kapoor, Kamaruddin Jaalam
  Diabetes Research and Clinical Practice.2022; 190: 109988.     CrossRef
• High Vaccenic Acid Content in Beef Fat Attenuates High Fat and High Carbohydrate Western Diet Induced Changes in Lipid Metabolism and Gut Microbiota in Pigs
  Vijay P. Singh, Melanie A. Fontaine, Rabban Mangat, Janelle M. Fouhse, Abdoulaye Diane, Benjamin P. Willing, Spencer D. Proctor
  Microorganisms.2021; 9(12): 2517.     CrossRef
• Inverse Association between High-Density Lipoprotein Cholesterol and Adverse Outcomes among Acute Ischemic Stroke Patients with Diabetes Mellitus
  Guoliang Hu, Yuesong Pan, Mengxing Wang, Xia Meng, Yong Jiang, Zixiao Li, Hao Li, Yongjun Wang, Yilong Wang
  Biomedicines.2021; 9(12): 1947.     CrossRef
• High Incidence of Diabetes in People with Extremely High High-Density Lipoprotein Cholesterol: Results of the Kanagawa Investigation of Total Checkup Data from the National Database-1 (KITCHEN-1)
  Kei Nakajima, Ryoko Higuchi, Taizo Iwane, Michi Shibata, Kento Takada, Michiko Sugiyama, Masafumi Matsuda, Teiji Nakamura
  Journal of Clinical Medicine.2019; 8(3): 381.     CrossRef
• Total adiponectin in overweight and obese subjects and its response to visceral fat loss
  Salah Gariballa, Juma Alkaabi, Javed Yasin, Awad Al Essa
  BMC Endocrine Disorders.2019;[Epub]     CrossRef
• Impaired Glucose Metabolism in People with Extremely Elevated High-Density Lipoprotein Cholesterol and Low Alcohol Consumption: Results of the Kanagawa Investigation of Total Checkup Data from the National Database-3 (KITCHEN-3)
  Kei Nakajima, Ryoko Higuchi
  Journal of Clinical Medicine.2019; 8(11): 1825.     CrossRef
• Phenotyping of Korean patients with better-than-expected efficacy of moderate-intensity statins using tensor factorization
  Jingyun Choi, Yejin Kim, Hun-Sung Kim, In Young Choi, Hwanjo Yu, Katriina Aalto-Setala
  PLOS ONE.2018; 13(6): e0197518.     CrossRef
• Serum Levels of Apolipoproteins and Incident Type 2 Diabetes: A Prospective Cohort Study
  Adela Brahimaj, Symen Ligthart, M. Arfan Ikram, Albert Hofman, Oscar H. Franco, Eric J.G. Sijbrands, Maryam Kavousi, Abbas Dehghan
  Diabetes Care.2017; 40(3): 346.     CrossRef
• Psoriasis and metabolic syndrome in children: current data
  A. Pietrzak, E. Grywalska, M. Walankiewicz, T. Lotti, J. Roliński, W. Myśliński, P. Chabros, D. Piekarska-Myślińska, K. Reich
  Clinical and Experimental Dermatology.2017; 42(2): 131.     CrossRef
• A Shift in ApoM/S1P Between HDL-Particles in Women With Type 1 Diabetes Mellitus Is Associated With Impaired Anti-Inflammatory Effects of the ApoM/S1P Complex
  Cecilia Frej, Armando J. Mendez, Mario Ruiz, Melanie Castillo, Thomas A. Hughes, Björn Dahlbäck, Ronald B. Goldberg
  Arteriosclerosis, Thrombosis, and Vascular Biology.2017; 37(6): 1194.     CrossRef
• Improvement in Biochemical Parameters in Patients with Type 2 Diabetes After Twenty-Four Sessions of Aerobic Exercise: A Randomized Controlled Trial
  Soulmaz Rahbar, Sedigheh Sadat Naimi, Asghar Reza Soltani, Abbas Rahimi, Alireza Akbarzadeh Baghban, Vahid Rashedi, Hossein Moein Tavakkoli
  Iranian Red Crescent Medical Journal.2017;[Epub]     CrossRef
• The therapeutic efficacy of intensive medical therapy in ameliorating high-density lipoprotein dysfunction in subjects with type two diabetes
  Sangeeta Kashyap, Karim Kheniser, Ling Li, James Bena, Takhar Kasumov
  Lipids in Health and Disease.2016;[Epub]     CrossRef
• Advances in high-density lipoprotein physiology: surprises, overturns, and promises
  Caterina Constantinou, Eleni A. Karavia, Eva Xepapadaki, Peristera-Ioanna Petropoulou, Eugenia Papakosta, Marilena Karavyraki, Evangelia Zvintzou, Vassilis Theodoropoulos, Serafoula Filou, Aikaterini Hatziri, Christina Kalogeropoulou, George Panayiotakopo
  American Journal of Physiology-Endocrinology and Metabolism.2016; 310(1): E1.     CrossRef
• Comparative analysis of the efficacy of omega-3 fatty acids for hypertriglyceridaemia management in Korea
  H.-S. Kim, H. Kim, Y. J. Jeong, S. J. Yang, S. J. Baik, H. Lee, S.-H. Lee, J. H. Cho, I.-Y. Choi, H. W. Yim, K.-H. Yoon
  Journal of Clinical Pharmacy and Therapeutics.2016; 41(5): 508.     CrossRef
• Analysis and comparison of statin prescription patterns and outcomes according to clinical department
  H.-S. Kim, H. Kim, H. Lee, B. Park, S. Park, S.-H. Lee, J. H. Cho, H. Song, J. H. Kim, K.-H. Yoon, I. Y. Choi
  Journal of Clinical Pharmacy and Therapeutics.2016; 41(1): 70.     CrossRef
• Statin‐related aminotransferase elevation according to baseline aminotransferases level in real practice in Korea
  H.‐S. Kim, S. H. Lee, H. Kim, S.‐H. Lee, J. H. Cho, H. Lee, H. W. Yim, S.‐H. Kim, I.‐Y. Choi, K.‐H. Yoon, J. H. Kim
  Journal of Clinical Pharmacy and Therapeutics.2016; 41(3): 266.     CrossRef
• Diabetes Associated to Atherosclerosis Risk Factors in Patients of Family Health Unity
  Polyane Medeiros Alves, Raiane dos Santos Pereira, Ariel Gustavo Letti, Álvaro Luís Müller da Fonseca
  Open Journal of Preventive Medicine.2015; 05(04): 177.     CrossRef
• Cis-9, trans-11 and trans-10, cis-12 CLA Mixture does not Change Body Composition, Induces Insulin Resistance and Increases Serum HDL Cholesterol Level in Rats
  Mariana Macedo de Almeida, Yamara Oliveira de Souza, Sheila Cristina Potente Dutra Luquetti, Céphora Maria Sabarense, José Otávio do Amaral Corrêa, Ellen Paula Santos da Conceição, Patrícia Cristina Lisboa, Egberto Gaspar de Moura, Sara Malaguti Andrade S
  Journal of Oleo Science.2015; 64(5): 539.     CrossRef
• Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
  Won-Young Lee
  Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
• Not All Smokers Die Young: A Model for Hidden Heterogeneity within the Human Population
  Morgan Levine, Eileen Crimmins, Hong Wei Chu
  PLoS ONE.2014; 9(2): e87403.     CrossRef
• Oxidative Damage and Inflammation in Obese Diabetic Emirati Subjects
  Salah Gariballa, Melita Kosanovic, Javed Yasin, Awad Essa
  Nutrients.2014; 6(11): 4872.     CrossRef
• Low HDL cholesterol is correlated to the acute ischemic stroke with diabetes mellitus
  Yun Luo, Jingwei Li, Junfeng Zhang, Yun Xu
  Lipids in Health and Disease.2014;[Epub]     CrossRef
• Butter naturally enriched in cis-9, trans-11 CLA prevents hyperinsulinemia and increases both serum HDL cholesterol and triacylglycerol levels in rats
  Mariana Macedo de Almeida, Sheila Cristina Potente Dutra Luquetti, Céphora Maria Sabarense, José Otávio do Amaral Corrêa, Larissa Gomes dos Reis, Ellen Paula Santos da Conceição, Patrícia Cristina Lisboa, Egberto Gaspar de Moura, Jacy Gameiro, Marco Antôn
  Lipids in Health and Disease.2014;[Epub]     CrossRef
• Conference report
  Andrew J. Krentz
  Cardiovascular Endocrinology.2014; 3(Supplement): S5.     CrossRef